The frequency with which you should change your refrigeration lubricant depends on a number of factors, including the type of lubricant you are using, the operating conditions of your refrigeration system, and the manufacturer's recommendations. In general, mineral oils should be changed every 1,000 to 2,000 hours of operation, while synthetic oils can last for 4,000 to 6,000 hours. It is always best to consult your manufacturer's recommendations for the specific lubricant you are using.